From cheverud at pcg.wustl.edu Sun Oct 4 23:22:03 2009 From: cheverud at pcg.wustl.edu (Jim Cheverud) Date: Sun, 4 Oct 2009 23:22:03 -0500 Subject: [Ctc] LG x SM proposal support Message-ID: <040201ca4573$66e6d580$34b48080$@wustl.edu> Dear Colleague, I am submitting a renewal of my NCRR-funded project "Mouse Models for Complex Disease". In this project we have produced 10 LGXSM RI strains from the F2 generation of the LG/J by SM/J intercross. We have also maintained an Advanced Intercross Line into the F42 generation and used it for fine-mapping. Additionally, we have been breeding a set of Advanced Recombinant Inbred Lines derived from the F34 generation of the Advanced Intercross Line. We have 57 of these strains at an average of F8 generations. This proposal is to maintain the existing strains, finish (genotype & cryopreserve) generating the new RI Lines, and to analyze the sequence of LG/J and SM/J which has recently been obtained. All strains, genotypes, and sequences will be made available to all. I would appreciate it if you could send an e-mail supporting my submission of this proposal. The proposal will be submitted on October 8, so the sooner, the better but even if you need more time, I would appreciate the support. The proposal is R24 RR015116 "Mouse Models for Complex Disease" Best wishes, James M. Cheverud Department of Anatomy & Neurobiology, Box 8108 Washington University School of Medicine 660 S. Euclid Avenue St. Louis, Missouri, 63110, USA Phone: 314-362-4188 FAX: 314-362-3446 E-mail: cheverud at pcg.wustl.edu -------------- next part -------------- An HTML attachment was scrubbed... URL: http://atlas.utmem.edu/pipermail/ctc/attachments/20091004/e528d123/attachment.html From french at niehs.nih.gov Thu Oct 8 13:56:02 2009 From: french at niehs.nih.gov (French, Jef (NIH/NIEHS) [E]) Date: Thu, 8 Oct 2009 14:56:02 -0400 Subject: [Ctc] Genetics Position Message-ID: Please see the USAJOBS advertisement below for details and online application. Applications will only be accepted online. http://jobview.usajobs.gov/getjob.aspx?JobID=83837476&q=Genetics&sort=rv%2c-dtex&vw=b&re=134&FedEmp=N&FedPub=Y&caller=default.aspx&jbf574=HE*&AVSDM=2009-10-08+00%3a03%3a00&rc=6&TabNum=1 This staff scientist position in genetics is located in the Host Susceptibility Branch, National Toxicology Program (NTP), Division of Intramural Research (DIR), National Institute of Environmental Health Sciences (NIEHS). NIEHS/NTP located in Research Triangle Park, North Carolina 27709, USA. The RTP is located central to the University of North Carolina at Chapel Hill, Duke University in Durham, NC, and North Carolina State University in Raleigh. http://www.niehs.nih.gov/ We are seeking a geneticist with strong computational and analytical skills to complement our multidisciplinary team to develop our research efforts in toxicogenetics. The research mission of the HSB is determine the biologic response to toxic agents of public health importance, the genetic and epigenetic basis for the variable biological response to toxic agent exposure, and identify the mode or mechanistic bases for agent specific associated toxicity that are highly conserved in order to improve the scientific basis for toxicology research and extrapolation across species. To accomplish this mission HSB scientists will use genetically diverse (GD) and genetically modified (GMM) inbred strains of mice to perform agent exposure specific ADME kinetics (absorption, distribution, metabolism, and excretion) and acute and adaptive toxicity intermediate phenotype analyses and functional evaluation of causally related genetic or epigenetic variants using contracted R&D laboratory resources. These data and biological samples for biomarker, molecular toxicology, and pathology analysis will be used along with whole genome based gene association studies to identify candidate causally related genes and their allelic variants. This NTP research and testing effort provides a basis for establishing multidisciplinary extramural and intramural research partnerships with scientists also investigating environmental exposure to toxic agents and increasing our ability and progress for identification of the causally related genes that are linked to the exposure using genetic models. By integrating toxicity phenotypes with the genetic basis for individual differences in biological responses, this research will support and aid in the improvement of quantitative risk assessment relevant to exposed human populations. Through translational research strategies, the results obtained may provide clues for epidemiology or corroboration of epidemiology research in animal models under defined exposure conditions, life stages, etc. For more information, contact: John E. French, Ph.D. Acting Chief, Host Susceptibility Branch National Toxicology Program National Institute of Environmental Health Sciences National Institutes of Health 111 T. W. Alexander Drive P. O. Box 12233, MD K2-08 Research Triangle Park, NC 27709 USA 919-541-2569 tel 919-542-3647 fax 919-208-1657 mobile french at niehs.nih.gov http://www.niehs.nih.gov/research/atniehs/labs/hsb/index.cfm For overnight express shipments: NIEHS, NIH 530 Davis Drive Keystone Bldg/Rm 2016 Morrisville, NC 27560 From mouseconference at gmail.com Mon Oct 12 15:57:13 2009 From: mouseconference at gmail.com (Lorelei Silverman) Date: Mon, 12 Oct 2009 16:57:13 -0400 Subject: [Ctc] Invitation to "Mouse models of diseases" conference Message-ID: <435bb8320910121357l66c5a89cp18de279bbe08594f@mail.gmail.com> Dear colleague:* * We would like to invite you to participate and present your work at the first on line global conference entitled *?Mouse models of diseases?* that will take place on February 25th, 2010. Based on preliminary response to our invitation we anticipate over 10 000 participants from US, Canada and worldwide. The conference is free for participants and at this time we request to submit only the title of your presentation, the name of the contributors, and the disease section of your area of research at mouseconference at gmail.com. The conference's aim is to provide an online forum for scientific exchange that will gather together scientists form academic institutions, research hospitals, biotech companies and life science consulting companies to share recent advances in understanding various diseases in the same cyberspace. The conference is open to any member of the biomedical research community who uses mouse as model organism irrespective of the research field and disease studied, of techniques and scientific approaches. The deadline for online abstract submission and registration as well as the disease sections can be found at the conference website at present under construction: http://www.wix.com/conferencenet/mouse The posters will be available post conference for further review and depending on the sponsorship received, awards of $100 for the best poster in each disease category (e.g. neurodegenerative, musculo-skeletal, cardiovascular, genetics, cancer, diabetes, endocrine, infectious, genito-urinary, haematological, dermatological, digestive, metabolic, respiratory, sensorial, immune) will recognize the most talented scientists. Our aim is to offer the opportunity to researchers worldwide to share their most recent discoveries in the biomedical field. By not charging a registration fee and having it online we hope to also offer the opportunity to scientists from developing countries to share their work, exchange ideas, forge new collaborations, and learn from others as most often they are prevented to attend similar conferences due to prohibitive transportation and accommodation costs. The organizing committee include scientists and medical doctors from University of Toronto, Faculty of Medicine, one of the oldest medical schools in North America and from USA. If interested to participate in this conference or to request additional information please contact the conference team at: mouseconference at gmail.com. PS. Please refer or forward this email to your colleagues. Sincerely, Co-chairs and scientific advisors Dr. Rosalind Silverman and Dr. Lorelei Silverman Dr. Rosalind Silverman University of Toronto, Faculty of Medicine, Department of Laboratory Medicine and Pathology 1 King's College Circle, room 6315,Toronto, ON, M5S1 A8, Canada phone: (416) 946-7134 email: rosalind.silverman.gavrila at utoronto.ca Dr. Lorelei Silverman University of Toronto, Faculty of Medicine, Department of Physiology Medical Sciences Building 1 King's College Circle, room 3308,Toronto, ON, M5S 1A8, Canada phone: (416) 978-0781 email: lorelei.silverman.gavrila at utoronto.ca Clifford Falk- computer specialist and legal advisor Dr. Sam Balderman-medical consultant Dr. Sophia Balderman-medical consultant Daniel Falk- computer specialist Thank you to our sponsors! -------------- next part -------------- An HTML attachment was scrubbed... URL: http://atlas.utmem.edu/pipermail/ctc/attachments/20091012/c6e7c805/attachment.html From Gary.Churchill at jax.org Fri Oct 16 13:08:33 2009 From: Gary.Churchill at jax.org (Gary Churchill) Date: Fri, 16 Oct 2009 14:08:33 -0400 Subject: [Ctc] QTL Archive Message-ID: As a courtesy to the genetic mapping community, we have created the QTL Archive (www.qtlarchive.org) a website that provides access to raw data from various QTL studies using rodent inbred line crosses. Data in the archive have been annotated and marker positions in mouse crosses have been translated to the most recent genome Build 37 (see Cox et al., Genetics, 2009). The data are available in the .csv format used by R/qtl, and in some cases are accompanied by analysis scripts. We are actively seeking new datasets for the archive. Please contact the QTL Archive curation team (qtlarchive at jax.org) if you are interested in submitting a dataset. Gary Churchill -------------- next part -------------- An HTML attachment was scrubbed... URL: http://atlas.utmem.edu/pipermail/ctc/attachments/20091016/f0ce3ae9/attachment.html From french at niehs.nih.gov Fri Oct 23 16:29:18 2009 From: french at niehs.nih.gov (French, Jef (NIH/NIEHS) [E]) Date: Fri, 23 Oct 2009 17:29:18 -0400 Subject: [Ctc] Geneticist Message-ID: Applications accepted online until November 5, 2009. http://jobview.usajobs.gov/GetJob.aspx?JobID=83837476&JobTitle=Geneticist+-+ NIEHS+-+DE&q=NIEHS&salmin=&salmax=&paygrademin=&paygrademax=&FedEmp=N&tm=&vw =d&brd=3876&ss=0&FedPub=Y&submit1.x=62&submit1.y=9&submit1=Search+for+Jobs&p g=1&cnme=Research+Triangle+Park&rad=5&rad_units=miles&re=0&AVSDM=2009-10-21+ 09%3a37%3a00 This position is located in the Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Institute of Environmental Health Sciences, National Toxicology Program (NTP), Host Susceptibility Branch. The Host Susceptibility Branch is seeking a Geneticist whose principal duties will be to serve as a study scientist. If you are an exceptionally talented and motivated individual with experience in this area, AND you want to play a significant role in a dynamic organization, then consider joining the NIEHS Branch in the National Toxicology Program (NTP). The Host Susceptibility Branch is responsible for the planning, conduct and analysis of assessments of chemical toxicity in multiple murine strains, and provides the resources to permit an understanding of the genetic basis for differences in susceptibility. New to the Government Application Process? We want to be sure you have an opportunity to be considered, so please review the information on the "Qualifications and Evaluations" tab and follow the instructions listed on the "How to Apply" tab. KEY REQUIREMENTS: * U.S. Citizenship From ltoth at siumed.edu Wed Oct 28 14:38:32 2009 From: ltoth at siumed.edu (Linda Toth) Date: Wed, 28 Oct 2009 14:38:32 -0500 Subject: [Ctc] Articles of potential interest in October Comparative Medicine Message-ID: <4AE89DB8.5050809@siumed.edu> The October issue of Comparative Medicine (vol. 59, No. 4) is now available. PLEASE FOLLOW THIS LINK TO ACCESS THE ISSUE: http://aalas.publisher.ingentaconnect.com/content/aalas/cm/2009/00000059/00000005;jsessionid=2e3paoajjtqdo.alice or http://tinyurl.com/ygxxqeb Infectious Diseases in Wild Mice (Mus musculus) Collected on and around the University of Pennsylvania (Philadelphia) Campus pp. 424-430(7) Authors: Parker, Sharon E.; Malone, Sarah; Bunte, Ralph M.; Smith, Abigail L. Adiposity-Related Biochemical Phenotype in Senescence-Accelerated Mouse Prone 6 (SAMP6) pp. 431-436(6) Authors: Niimi, Kimie; Takahashi, Eiki; Itakura, Chitoshi * If you would like more information on how to become an AALAS member please go to http://www.aalas.org/association/membership.aspx. To subscribe to Comparative Medicine, go to http://www.aalas.org/pdf/Subscription_CM.pdf. *For more information on how to submit an article to Comparative Medicine, please go to http://www.aalas.org/publications/cm_info_for_au.asp. *For any other questions regarding the journals, please e-mail us at journals at aalas.org. -- Linda Toth, D.V.M., Ph.D. Associate Dean for Research and Faculty Affairs Professor, Department of Pharmacology Southern Illinois University School of Medicine 801 North Rutledge Street Box 19616 Springfield, IL 62794-9616 Phone 217-545-7936 Fax 217-545-7873 From niels.kruize at kbioscience.co.uk Fri Oct 30 10:53:35 2009 From: niels.kruize at kbioscience.co.uk (Niels Kruize / KBiosciences) Date: Fri, 30 Oct 2009 16:53:35 +0100 Subject: [Ctc] DNA Fragmentation: The Critical First Step in Next Generation Sequencing Message-ID: <20091030.IYWHJXNATOAYFAXZ@kbioscience.co.uk> Topic:Controlled DNA Fragmentation: The Critical First Step in Next Generation Sequencing When: November 11, 2009 Time: 11:00a.m. EST Duration: Presentation: 30 Minutes Discussion: 30 Minutes Hosts: Introduction: Jim Laugharn, Founder and CEO Presentation: Hamid Khoja, Ph.D., Senior Applications Scientist Registration: To register for the online event: 1. Click here 2. Click Register 3. On the registration form, enter your information and then click Submit. You will receive a confirmation email and an event reminder. What You Will Learn: The important role of Controlled DNA Fragmentation in the sample preparation process for Next Generation Sequencing. What DNA Fragmentation methods are commercially available today for Fragment and Mate-Pair Libraries. How the Covaris AFA process works. Additional key applications and services. Webinar Abstract: DNA fragmentation is the most critical sample preparation step required by all the currently available next generation sequencing platforms. The sensitivity and broader application depth of these platforms necessitates the utilization of an efficient, easy to use, high throughput capable, and highly reproducible DNA fragmentation technology. Although nebulization, enzymatic digestion, hydrodynamic shearing, and sonication have been used to shear DNA, they all have significant disadvantages, which cause them to be a weak point in the workflow for next generation sequencing technologies. Drawbacks include thermal and sequence specific biased shearing, thermal degradation, sample loss, automation difficulties, and user-based issues. The Covaris AFA process stands out as the preferred method for easily and reproducibly fragmenting DNA ranging from 100bp to 5kb in length. In this meeting we will provide details of the Covaris AFA technology, and the distinct advantages it provides when compared to other DNA shearing methodologies. We will also present data to showcase the control and reproducibility of our validated protocols when fragmenting DNA in the 100bp to 5kb size range. Also discussed will be the use of AFA technology in chromatin fragmentation for ChIP-chip, ChIP-seq, and RNA fragmentation applications. About Covaris At Covaris, we believe that high value samples deserve controlled preparation, prior to committing to high cost analysis. Covaris' line of high-performance focused ultra-sonicators deliver industry-leading sample processing capability directly to the benchtop. We provide workstation-based instruments capable of extremely rapid and complete DNA/RNA/Chromatin fragmentation, tissue disruption, and non-contact isothermal homogenization of cell culture, tissue, and organisms for DNA, RNA, protein, and metabolites extraction. The Covaris family of instruments provides single through 96 sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. With over 850 installations, the Covaris proprietary and patented Adaptive Focused Acoustics? (AFA) technology enables numerous non-contact, isothermal sample preparation processes for use in a broad range of applications including Genomics, Proteomics, and Drug Discovery research. For more information about Covaris and AFA, please visit us at Covarisinc.com or on KBioscience. You are currently receiving this newsletter as: ctc at atlas.utmem.edu. To unsubscribe and discontinue mailings, please send a blank email with the subject "unsubscribe" to Postmaster at nkbio.nl. -------------- next part -------------- An HTML attachment was scrubbed... URL: http://atlas.utmem.edu/pipermail/ctc/attachments/20091030/7a40d327/attachment-0001.html